L Arginine Information
(Enhance your erections with L Arginine)

 

Source:
L Arginine - is an essential amino acid (the body cannot create the amino acid on its own it must be ingested). Arginine is found in many foods, including dairy products, meat, fish and poultry.

 

How L Arginine Increase Blood Flow to the Penis
(Better erections with L Arginine in the corpus cavernosum)

Physiology:
L-arginine promotes the erection process by acting as a precursor to the formation of nitrous oxide. During the normal male erection process blood flow is directed into the corpus cavernosum. The corpus cavernosum consists of “sponge like” tissue which runs the length of the penis. As the corpus cavernosum fills with blood, it expands and begins to press against the body of the penis. This pressure closes the veins reducing their ability to carry blood away from the penis. The reduction in venous blood flow, known as venous occlusion, allows blood to be trapped in the corpus cavernosum. This process continues until the pressure in the corpus cavernosum equals the pressure of the corpus cavernosal arteries. It is at this point that the penis is fully erect.



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The engorgement of the corpus cavernosum and subsequent erection is triggered by a short-lived neurotransmitter, nitric oxide. Nitric oxide is synthesized from the oxidation of the amino acid L arginine. In order to produce nitric oxide in the body, a terminal nitrogen atom must combine with an oxygen molecule in the blood. An enzyme called nitric oxide synthase controls this reaction and NADPH, niacin-containing redox-active electron storage compound, mediates the reaction. This reaction can be accomplished via oral ingestion of formulas that contain the free form amino acid L-arginine. The left-handed molecule, L-arginine, is the primary source for Nitric Oxide in humans.

Once synthesized nitrous oxide activates an enzyme that manufactures cyclic guanosine monophosphate (cGMP), a biochemical signaling enzyme. The cGMP, directs the smooth muscle cells to relax, leading to the dilation of penile arteries and the subsequent filling of the corpus cavernosum. Immediately following the release of nitrous oxide and production of cGMP, another enzyme, cGMP phosphodiesterase Type 5 named PDE-5, is activated. PDE-5’s main activity is to break down cGMP almost as fast as it is formed. The result of this breakdown of cGMP by PDE-5 is a rapid decrease in smooth muscle relaxation and a loss of blood flow to the penis. Subsequently, the penis returns to its flaccid state.

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Clinical Studies:
L-arginine through its oxidation process to nitric oxide, plays a significant role in the erection process. Research has shown that increased levels of nitric oxide can correct up to 90% of the clinical cases of erectile dysfunction. The role of nitric oxide in controlling blood flow was only recently discovered in 1998 resulting in a Nobel Prize for scientific discovery. From this discovery, the researchers at Physicians’ Select further researched the importance of L-Arginine in our male libido enhancer supplement to promote the optimal male sexual response.

 Modern day uses:
In addition to promoting the erectile response L arginine also is beneficial in the following ways:

  • Necessary for spermatogenesis
  • Precursor amino acid to human growth hormone
  • Essential for normal immune system activity
  • Promotes muscle growth and fat burning
  • Assists with regeneration of damaged liver
  • Necessary for production and release of growth hormone
  • A precursor to Creatine and the neurotransmitter nitric oxide
  • Arginine is crucial to the wound healing process through collagen synthesis, particularly in the elderly who suffer from poor circulation
  • Arginine is the most potent amino acid in releasing insulin.
  • Precursor to GABA, an important inhibitory neurotransmitter
  • Improves immune response to bacteria, viruses, and tumor cells
  • Supplementation of the amino acid can reduce the pathological increases in the thickness of plaque lined vessel walls in individuals with elevated cholesterol and arthrosclerosis

Precautions and/or adverse effects:
Individuals with preexisting medical conditions should consult with their physician particularly if they are taking prescription or over-the-counter-medications or supplements. Women who are pregnant or breast feeding and children should also consult with there physician prior to taking any new supplements.

More specifically, individuals should not take Arginine supplements if they are predisposed to any the following medical conditions:

  • Cancer
  • Low blood pressure
  • Liver or Kidney disease
  • Individuals on blood thinners
  • Psychological conditions, such as, psychosis
  • Diabetics and borderline diabetics
  • Individuals who have not completed their bone growth i.e. children and/or teenagers
  • Individuals with acute or chronic viral conditions i.e. Epstein-Barr Virus (EBV),
  • Cytomegalovirus (CMV), Herpes Virus, Human Immunodeficiency Virus (HIV)

There are very few side effects associated with the supplemental use of the herb. Though, individuals may experience an increase in cold sores or herpetic lesions  (increase doses of arginine may promote the outbreak if herpes simplex in individuals who have the virus). Excessive dosage of arginine may also cause diarrhea, stomach cramps, bloating, swelling in the lower extremities.

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